TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population
Joint Authors
Hua, Wei
Li, Xiaoping
Wang, Huan
Zhang, Channa
Zhang, Yu
Hui, Rutai
Wu, Xiushan
Gu, Haiyong
Luo, Rong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Idiopathic dilated cardiomyopathy (DCM) is characterized by ventricular chamber enlargement and systolic dysfunction.
The pathogenesis of DCM remains uncertain, and the TNNT2 gene is potentially associated with DCM.
To assess the role of TNNT2 in DCM, we examined 10 tagging single nucleotide polymorphisms (SNPs) in the patients.
Methods.
A total of 97 DCM patients and 189 control subjects were included in the study, and all SNPs were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Results.
In the TNNT2 gene, there was a significant association between DCM and genotype for the tagging SNPs rs3729547 (χ2=6.63, P=0.036, OR=0.650, and 95% CI = 0.453–0.934) and rs3729843 (χ2=9.787, P=0.008, OR=1.912, and 95% CI = 1.265–2.890) in the Chinese Han population.
Linkage disequilibrium (LD) analysis showed that the SNPs rs7521796, rs2275862, rs3729547, rs10800775, and rs1892028, which are approximately 6 kb apart, were in high LD (D′>0.80) in the DCM patients.
Conclusion.
These results suggest that the TNNT2 polymorphisms might play an important role in susceptibility to DCM in the Chinese Han population.
American Psychological Association (APA)
Li, Xiaoping& Wang, Huan& Luo, Rong& Gu, Haiyong& Zhang, Channa& Zhang, Yu…[et al.]. 2013. TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030189
Modern Language Association (MLA)
Li, Xiaoping…[et al.]. TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030189
American Medical Association (AMA)
Li, Xiaoping& Wang, Huan& Luo, Rong& Gu, Haiyong& Zhang, Channa& Zhang, Yu…[et al.]. TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030189