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Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A2
Joint Authors
He, Shaoheng
Wei, Xiao-Long
Mo, Ya-Zhen
Yang, Haiwei
Wei, Ji-Fu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Local inflammation is a prominent characteristic of snakebite wound, and snake-venom phospholipase A2s (PLA2s) are some of the main component that contribute to accumulation of inflammatory cells.
However, the action of an R49 PLA2s, promutoxin from Protobothrops mucrosquamatus venom, on mast-cell accumulation has not been previously examined.
Using a mouse peritoneal model, we found that promutoxin can induce approximately-6-fold increase in mast-cell accumulation, and the response lasts at least for 16 h.
The promutoxin-induced mast cell accumulation was inhibited by cyproheptadine, terfenadine, and Ginkgolide B, indicating that histamine and platelet-activating factor (PAF) is likely to contribute to the mast-cells accumulation.
Preinjection of antibodies against adhesion molecules ICAM-1, CD18, CD11a, and L-selectin showed that ICAM-1, and CD18, CD11a are key adhesion molecules of promutoxin-induced mast-cell accumulation.
In conclusion, promutoxin can induce accumulation of mast cells, which may contribute to snake-venom wound.
American Psychological Association (APA)
Wei, Ji-Fu& Wei, Xiao-Long& Mo, Ya-Zhen& Yang, Haiwei& He, Shaoheng. 2012. Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A2. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030198
Modern Language Association (MLA)
Wei, Ji-Fu…[et al.]. Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A2. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030198
American Medical Association (AMA)
Wei, Ji-Fu& Wei, Xiao-Long& Mo, Ya-Zhen& Yang, Haiwei& He, Shaoheng. Induction of Mast-Cell Accumulation by Promutoxin, an Arg-49 Phospholipase A2. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030198