Merit of Anisodamine Combined with Opioid δ-Receptor Activation in the Protection against Myocardial Injury during Cardiopulmonary Bypass
Joint Authors
Hong, Xuan
Fan, Huimin
Lu, Rong
Liu, Zhongmin
Chan, Paul
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myocardial ischemia/reperfusion (MIR) injury easily occurrs during cardiopulmonary bypass surgery in elderly patients.
In an attempt to develop an effective strategy, we employed a pig model of MIR injury to investigate the maximum rate of change of left ventricular pressure, left ventricular enddiastolic pressure, and left intraventricular pressure.
Coronary sinus cardiac troponin T (TnT) and adenosine-triphosphate (ATP) content in myocardium were measured.
The ultrastructures for MIR injury were visualized by transmission electron microscopy (TEM).
The role of δ-opioid receptor activation using D-Ala2, D-Leu5-enkephalin (DADLE) in both early (D1) and late (D2) phases of cardioprotection was identified.
Also, the merit of cardioprotection by DADLE in combination with anisodamine, the muscarinic receptor antagonist (D+M), was evaluated.
Glibenclamide was employed at the dose sufficient to block ATP-sensitive potassium channels.
Significant higher cardiac indicators, reduced TnT and increased ATP contents, were observed in D1, D2, and D+M groups compared with the control group.
DADLE induced protection was better in later phase of ischemia that was attenuated by glibenclamide.
DADLE after the ischemia showed no benefit, but combined treatment with anisodamine showed a marked postischemic cardioprotection.
Thus, anisodamine is helpful in combination with DADLE for postischemic cardioprotection.
American Psychological Association (APA)
Hong, Xuan& Fan, Huimin& Lu, Rong& Chan, Paul& Liu, Zhongmin. 2013. Merit of Anisodamine Combined with Opioid δ-Receptor Activation in the Protection against Myocardial Injury during Cardiopulmonary Bypass. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030204
Modern Language Association (MLA)
Hong, Xuan…[et al.]. Merit of Anisodamine Combined with Opioid δ-Receptor Activation in the Protection against Myocardial Injury during Cardiopulmonary Bypass. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030204
American Medical Association (AMA)
Hong, Xuan& Fan, Huimin& Lu, Rong& Chan, Paul& Liu, Zhongmin. Merit of Anisodamine Combined with Opioid δ-Receptor Activation in the Protection against Myocardial Injury during Cardiopulmonary Bypass. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030204