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A Simple Model for Assessment of Anti-Toxin Antibodies
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The toxins associated with infectious diseases are potential targets for inhibitors which have the potential for prophylactic or therapeutic use.
Many antibodies have been generated for this purpose, and the objective of this study was to develop a simple mathematical model that may be used to evaluate the potential protective effect of antibodies.
This model was used to evaluate the contributions of antibody affinity and concentration to reducing antibody-receptor complex formation and internalization.
The model also enables prediction of the antibody kinetic constants and concentration required to provide a specified degree of protection.
We hope that this model, once validated experimentally, will be a useful tool for in vitro selection of potentially protective antibodies for progression to in vivo evaluation.
American Psychological Association (APA)
Skvortsov, Alex& Gray, Peter. 2013. A Simple Model for Assessment of Anti-Toxin Antibodies. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030207
Modern Language Association (MLA)
Skvortsov, Alex& Gray, Peter. A Simple Model for Assessment of Anti-Toxin Antibodies. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030207
American Medical Association (AMA)
Skvortsov, Alex& Gray, Peter. A Simple Model for Assessment of Anti-Toxin Antibodies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030207