End-Systolic Elastance and Ventricular-Arterial Coupling Reserve Predict Cardiac Events in Patients with Negative Stress Echocardiography
Joint Authors
Sicari, R.
Bombardini, Tonino
Costantino, Marco Fabio
Ciampi, Quirino
Picano, Eugenio
Pratali, Lorenza
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
A maximal negative stress echo identifies a low-risk subset for coronary events.
However, the potentially prognostically relevant information on cardiovascular hemodynamics for heart-failure-related events is unsettled.
Aim of this study was to assess the prognostic value of stress-induced variation in cardiovascular hemodynamics in patients with negative stress echocardiography.
Methods.
We enrolled 891 patients (593 males mean age 63±12, ejection fraction 48±17%), with negative (exercise 172, dipyridamole 482, and dobutamine 237) stress echocardiography result.
During stress we assessed left ventricular end-systolic elastance index (ELVI), ventricular arterial coupling (VAC) indexed by the ratio of the ELVI to arterial elastance index (EaI), systemic vascular resistance (SVR), and pressure-volume area (PVA).
Changes from rest to peak stress (reserve) were tested as predictors of main outcome measures: combined death and heart failure hospitalization.
Results.
During a median followup of 19 months (interquartile range 8–36), 50 deaths and 84 hospitalization occurred.
Receiver-operating-characteristic curves identified as best predictors ELVI reserve for exercise (AUC = 0.871) and dobutamine (AUC = 0.848) and VAC reserve (AUC = 0.696) for dipyridamole.
Conclusions.
Patients with negative stress echocardiography may experience an adverse outcome, which can be identified by assessment of ELVI reserve and VAC reserve during stress echo.
American Psychological Association (APA)
Bombardini, Tonino& Costantino, Marco Fabio& Sicari, R.& Ciampi, Quirino& Pratali, Lorenza& Picano, Eugenio. 2013. End-Systolic Elastance and Ventricular-Arterial Coupling Reserve Predict Cardiac Events in Patients with Negative Stress Echocardiography. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030210
Modern Language Association (MLA)
Bombardini, Tonino…[et al.]. End-Systolic Elastance and Ventricular-Arterial Coupling Reserve Predict Cardiac Events in Patients with Negative Stress Echocardiography. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030210
American Medical Association (AMA)
Bombardini, Tonino& Costantino, Marco Fabio& Sicari, R.& Ciampi, Quirino& Pratali, Lorenza& Picano, Eugenio. End-Systolic Elastance and Ventricular-Arterial Coupling Reserve Predict Cardiac Events in Patients with Negative Stress Echocardiography. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030210