An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation
Joint Authors
Petros, John A.
Sun, Qian
Sun, Carrie Q.
Richards, Jendai C.
O'Hearn, Sean
Wallace, Douglas C.
Osunkoya, Adeboye O.
Arnold, Rebecca S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mitochondrial DNA (mtDNA) mutations have been found in many cancers but the physiological derangements caused by such mutations have remained elusive.
Prostate cancer is associated with both inherited and somatic mutations in the cytochrome c oxidase (COI) gene.
We present a prostate cancer patient-derived rare heteroplasmic mutation of this gene, part of mitochondrial respiratory complex IV.
Functional studies indicate that this mutation leads to the simultaneous decrease in cytochrome oxidation, increase in reactive oxygen, and increased reactive nitrogen.
These data suggest that mitochondrial DNA mutations resulting in increased reactive oxygen and reactive nitrogen generation may be involved in prostate cancer biology.
American Psychological Association (APA)
Arnold, Rebecca S.& Sun, Qian& Sun, Carrie Q.& Richards, Jendai C.& O'Hearn, Sean& Osunkoya, Adeboye O.…[et al.]. 2012. An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030214
Modern Language Association (MLA)
Arnold, Rebecca S.…[et al.]. An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030214
American Medical Association (AMA)
Arnold, Rebecca S.& Sun, Qian& Sun, Carrie Q.& Richards, Jendai C.& O'Hearn, Sean& Osunkoya, Adeboye O.…[et al.]. An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030214