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18F-FDG PET in the Diagnosis and Treatment of Primary Central Nervous System Lymphoma
Joint Authors
Miyake, Keisuke
Tamiya, Takashi
Kawai, Nobuyuki
Yamamoto, Yuka
Nishiyama, Yoshihiro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This paper summarizes the usefulness and limitation of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) in the diagnosis and treatment of primary central nervous system lymphoma (PCNSL).
The 18F-FDG uptake in typical PCNSL is about 2.5 times higher than that in the normal gray matter, and the tumor can usually be identified visually.
The 18F-FDG uptake pattern and value provide useful information for differentiating PCNSL from other enhancing malignant brain tumors especially glioblastoma (GB).
The 18F-FDG uptake in typical PCNSL is usually homogenous, and the uptake value is significantly higher than that in GB.
However, 18F-FDG PET often fails to show the presence of tumor in the brain as 18F-FDG uptake is faint in atypical PCNSL such as disseminated or nonenhancing lesions.
18F-FDG PET is also useful for evaluating the treatment response at a very early stage after the initial treatment.
Pretreatment and posttreatment 18F-FDG uptake values may have a prognostic value in patients with PCNSL.
In conclusion, 18F-FDG PET is very useful in the diagnosis of typical PCNSL and can differentiate PCNSL from other malignant brain tumors.
However, the usefulness of 18F-FDG PET is limited in the diagnosis of atypical PCNSL.
American Psychological Association (APA)
Kawai, Nobuyuki& Miyake, Keisuke& Yamamoto, Yuka& Nishiyama, Yoshihiro& Tamiya, Takashi. 2013. 18F-FDG PET in the Diagnosis and Treatment of Primary Central Nervous System Lymphoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030221
Modern Language Association (MLA)
Kawai, Nobuyuki…[et al.]. 18F-FDG PET in the Diagnosis and Treatment of Primary Central Nervous System Lymphoma. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030221
American Medical Association (AMA)
Kawai, Nobuyuki& Miyake, Keisuke& Yamamoto, Yuka& Nishiyama, Yoshihiro& Tamiya, Takashi. 18F-FDG PET in the Diagnosis and Treatment of Primary Central Nervous System Lymphoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030221