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Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma
Joint Authors
Herbert, Cristan
Bunting, Melissa M.
Shadie, Alexander M.
Flesher, Rylie P.
Nikiforova, Valentina
Garthwaite, Linda
Tedla, Nicodemus
Kumar, Rakesh K.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the role of interleukin-33 (IL-33) in airway inflammation in an experimental model of an acute exacerbation of chronic asthma, which reproduces many of the features of the human disease.
Systemically sensitized female BALB/c mice were challenged with a low mass concentration of aerosolized ovalbumin for 4 weeks to induce chronic asthmatic inflammation and then received a single moderate-level challenge to trigger acute airway inflammation simulating an asthmatic exacerbation.
The inflammatory response and expression of cytokines and activation markers by alveolar macrophages (AM) were assessed, as was the effect of pretreatment with a neutralizing antibody to IL-33.
Compared to chronically challenged mice, AM from an acute exacerbation exhibited significantly enhanced expression of markers of alternative activation, together with enhanced expression of proinflammatory cytokines and of cell surface proteins associated with antigen presentation.
In parallel, there was markedly increased expression of both mRNA and immunoreactivity for IL-33 in the airways.
Neutralization of IL-33 significantly decreased both airway inflammation and the expression of proinflammatory cytokines by AM.
Collectively, these data indicate that in this model of an acute exacerbation of chronic asthma, IL-33 drives activation of AM and has an important role in the pathogenesis of airway inflammation.
American Psychological Association (APA)
Bunting, Melissa M.& Shadie, Alexander M.& Flesher, Rylie P.& Nikiforova, Valentina& Garthwaite, Linda& Tedla, Nicodemus…[et al.]. 2013. Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030233
Modern Language Association (MLA)
Bunting, Melissa M.…[et al.]. Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030233
American Medical Association (AMA)
Bunting, Melissa M.& Shadie, Alexander M.& Flesher, Rylie P.& Nikiforova, Valentina& Garthwaite, Linda& Tedla, Nicodemus…[et al.]. Interleukin-33 Drives Activation of Alveolar Macrophages and Airway Inflammation in a Mouse Model of Acute Exacerbation of Chronic Asthma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030233