Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade
Joint Authors
Gorrasi, José
Eleftheriadis, Anestis
Brandt, Sebastian
Djafarzadeh, Siamak
Bruegger, Lukas E.
Bracht, Hendrik
Takala, Jukka
Jakob, Stephan M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Changes in hepatosplanchnic lactate exchange are likely to contribute to hyperlactatemia in sepsis.
We hypothesized that septic and cardiogenic shock have different effects on hepatosplanchnic lactate exchange and its contribution to hyperlactatemia.
Materials and Methods.
24 anesthetized pigs were randomized to fecal peritonitis (P), cardiac tamponade (CT), and to controls (n=8 per group).
Oxygen transport and lactate exchange were calculated during 24 hours.
Results.
While hepatic lactate influx increased in P and in CT, hepatic lactate uptake remained unchanged in P and decreased in CT.
Hepatic lactate efflux contributed 20% (P) and 33% (CT), respectively, to whole body venous efflux.
Despite maintained hepatic arterial blood flow, hepatic oxygen extraction did not increase in CT.
Conclusions.
Whole body venous lactate efflux is of similar magnitude in hyperdynamic sepsis and in cardiogenic shock.
Although jejunal mucosal pCO2 gradients are increased, enhanced lactate production from other tissues is more relevant to the increased arterial lactate.
Nevertheless, the liver fails to increase hepatic lactate extraction in response to rising hepatic lactate influx, despite maintained hepatic oxygen consumption.
In cardiac tamponade, regional, extrasplanchnic lactate production is accompanied by hepatic failure to increase oxygen extraction and net hepatic lactate output, despite maintained hepatic arterial perfusion.
American Psychological Association (APA)
Gorrasi, José& Eleftheriadis, Anestis& Takala, Jukka& Brandt, Sebastian& Djafarzadeh, Siamak& Bruegger, Lukas E.…[et al.]. 2013. Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030234
Modern Language Association (MLA)
Gorrasi, José…[et al.]. Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030234
American Medical Association (AMA)
Gorrasi, José& Eleftheriadis, Anestis& Takala, Jukka& Brandt, Sebastian& Djafarzadeh, Siamak& Bruegger, Lukas E.…[et al.]. Different Contribution of Splanchnic Organs to Hyperlactatemia in Fecal Peritonitis and Cardiac Tamponade. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030234