Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?
Joint Authors
Anousha, Negin
Biramijamal, Firouzeh
Rahmani, Ali
Maghbooli, Zhila
Aghababaei, Elahe
Nemati, Shahram
Hossein-Nezhad, Arash
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Estrogen plays a crucial role in fetal and placental development through estrogen receptors.
Association of estrogen receptor alpha gene (ESR1) polymorphisms with spontaneous abortion has been shown in some studies.
Our main goal was to study the potential association of spontaneous abortion with the ESR1 gene variations (PvuII and XbaI) in fetal tissue.
Totally, 161 samples were recruited including 80 samples of formalin-fixed paraffin-embedded fetal tissue from spontaneous abortion and 81 samples of normal term placental tissue.
The restriction fragment length polymorphism (RFLP) method was performed for genotyping the rs2234693 (A/G XbaI) and rs9340799 (T/C PvuII) single nucleotide polymorphisms located in intron 1 of ESR1.
The results have been confirmed by DNA sequencing analysis.
The different genotypes distribution was detected in two study groups.
Haplotype analysis indicated that ppxx is protective genotype against spontaneous abortion (P = 0.01).
In conclusion, the potential role of ESR1 genetic variation in spontaneous abortion might be valuable in high-risk subjects, and that needs to be confirmed with future studies.
American Psychological Association (APA)
Anousha, Negin& Hossein-Nezhad, Arash& Biramijamal, Firouzeh& Rahmani, Ali& Maghbooli, Zhila& Aghababaei, Elahe…[et al.]. 2013. Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030248
Modern Language Association (MLA)
Anousha, Negin…[et al.]. Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030248
American Medical Association (AMA)
Anousha, Negin& Hossein-Nezhad, Arash& Biramijamal, Firouzeh& Rahmani, Ali& Maghbooli, Zhila& Aghababaei, Elahe…[et al.]. Association Study of Estrogen Receptor Alpha Gene Polymorphisms with Spontaneous Abortion: Is This a Possible Reason for Unexplained Spontaneous Abortion?. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030248