Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii
Joint Authors
Husain, Fohad Mabood
Zahin, Maryam
Aqil, Farrukh
Ahmad, Iqbal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It is well known that the intake of antioxidants with increased consumption of fruits and vegetables and medicinal herbs contributes towards reduced risk of certain diseases including cancers.
This study aims to evaluate the broad-spectrum antioxidant and antimutagenic activities as well as to elucidate phytochemical profile of an Indian medicinal plant Murraya koenigii (curry) leaves.
Leaves of the plant were successively fractionated in various organic solvents.
Benzene fraction demonstrated the highest phenolic content followed by petroleum ether.
The benzene fraction showed maximum antioxidant activity in all tested assays, namely, phosphomolybdenum, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, ferric reducing antioxidant power (FRAP) and cupric reducing antioxidant capacity (CUPRAC) assays.
Based on the promising broad-spectrum antioxidant activity, benzene fraction was further evaluated for antimutagenic activity and showed a dose-dependent antimutagenic response in Ames Salmonella mutagenicity assay.
It inhibited 72–86% mutagenicity induced by sodium azide, methyl methanesulfonate, benzo(a)pyrene, and 2-aminoflourene at the maximum tested concentration (100 μg/mL) in Salmonella typhimurium tester strains.
At least 21 compounds were detected by GC/MS.
The findings clearly demonstrated that phenolic-rich benzene fraction has promising broad-spectrum antioxidant and antimutagenic property and needs further evaluation to exploit its therapeutic potential.
American Psychological Association (APA)
Zahin, Maryam& Aqil, Farrukh& Husain, Fohad Mabood& Ahmad, Iqbal. 2013. Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030255
Modern Language Association (MLA)
Zahin, Maryam…[et al.]. Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030255
American Medical Association (AMA)
Zahin, Maryam& Aqil, Farrukh& Husain, Fohad Mabood& Ahmad, Iqbal. Antioxidant Capacity and Antimutagenic Potential of Murraya koenigii. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030255