Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network
Joint Authors
Zhang, Jian
Zhang, Ning
Huang, Tao
You, Jin
Chen, Lei
Cai, Yu-Dong
Li, Hai-Peng
Li, Bi-Qing
Kong, Xiangyin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lung cancer is one of the leading causes of cancer mortality worldwide.
The main types of lung cancer are small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC).
In this work, a computational method was proposed for identifying lung-cancer-related genes with a shortest path approach in a protein-protein interaction (PPI) network.
Based on the PPI data from STRING, a weighted PPI network was constructed.
54 NSCLC- and 84 SCLC-related genes were retrieved from associated KEGG pathways.
Then the shortest paths between each pair of these 54 NSCLC genes and 84 SCLC genes were obtained with Dijkstra’s algorithm.
Finally, all the genes on the shortest paths were extracted, and 25 and 38 shortest genes with a permutation P value less than 0.05 for NSCLC and SCLC were selected for further analysis.
Some of the shortest path genes have been reported to be related to lung cancer.
Intriguingly, the candidate genes we identified from the PPI network contained more cancer genes than those identified from the gene expression profiles.
Furthermore, these genes possessed more functional similarity with the known cancer genes than those identified from the gene expression profiles.
This study proved the efficiency of the proposed method and showed promising results.
American Psychological Association (APA)
Li, Bi-Qing& You, Jin& Chen, Lei& Zhang, Jian& Zhang, Ning& Li, Hai-Peng…[et al.]. 2013. Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030262
Modern Language Association (MLA)
Li, Bi-Qing…[et al.]. Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030262
American Medical Association (AMA)
Li, Bi-Qing& You, Jin& Chen, Lei& Zhang, Jian& Zhang, Ning& Li, Hai-Peng…[et al.]. Identification of Lung-Cancer-Related Genes with the Shortest Path Approach in a Protein-Protein Interaction Network. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030262