Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium
Joint Authors
Morales-Montor, Jorge
Palacios-Arreola, M. Isabel
Olivos, Alfonso
López-Griego, Lorena
Escobedo, Galileo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human neurocysticercosis by Taenia solium is considered an emergent severe brain disorder in developing and developed countries.
Discovery of new antiparasitic drugs has been recently aimed to restrain differentiation and establishment of the T.
solium adult tapeworm, for being considered a central node in the disease propagation to both pigs and humans.
Tamoxifen is an antiestrogenic drug with cysticidal action on Taenia crassiceps, a close relative of T.
solium.
Thus, we evaluated the effect of tamoxifen on the in vitro evagination and the in vivo establishment of T.
solium.
In vitro, tamoxifen inhibited evagination of T.
solium cysticerci in a dose-time dependent manner.
In vivo, administration of tamoxifen to hamsters decreased the intestinal establishment of the parasite by 70%, while recovered tapeworms showed an 80% reduction in length, appearing as scolices without strobilar development.
Since tamoxifen did not show any significant effect on the proliferation of antigen-specific immune cells, intestinal inflammation, and expression of Th1/Th2 cytokines in spleen and duodenum, this drug could exert its antiparasite actions by having direct detrimental effects upon the adult tapeworm.
These results demonstrate that tamoxifen exhibits a strong cysticidal and antitaeniasic effect on T.
solium that should be further explored in humans and livestock.
American Psychological Association (APA)
Escobedo, Galileo& Palacios-Arreola, M. Isabel& Olivos, Alfonso& López-Griego, Lorena& Morales-Montor, Jorge. 2012. Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030281
Modern Language Association (MLA)
Escobedo, Galileo…[et al.]. Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030281
American Medical Association (AMA)
Escobedo, Galileo& Palacios-Arreola, M. Isabel& Olivos, Alfonso& López-Griego, Lorena& Morales-Montor, Jorge. Tamoxifen Treatment in Hamsters Induces Protection during Taeniosis by Taenia solium. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030281