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Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research
Joint Authors
Pedraz, José Luis
Mata, Elena
Salvador, Aiala
Igartua, Manoli
Hernández, Rosa Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-23
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria.
Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets.
Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance.
Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants) as well as the immunostimulatory effect of the formulation components (immunostimulants) modulates the immune response elicited.
Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses.
This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.
American Psychological Association (APA)
Mata, Elena& Salvador, Aiala& Igartua, Manoli& Hernández, Rosa Maria& Pedraz, José Luis. 2013. Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research. BioMed Research International،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1030291
Modern Language Association (MLA)
Mata, Elena…[et al.]. Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research. BioMed Research International No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-1030291
American Medical Association (AMA)
Mata, Elena& Salvador, Aiala& Igartua, Manoli& Hernández, Rosa Maria& Pedraz, José Luis. Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-1030291
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030291