Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes
Joint Authors
Visentainer, Jeane Eliete Laguila
Ayo, Christiane Maria
Dalalio, Márcia Machado de Oliveira
Jarduli, Luciana Ribeiro
Sell, Ana Maria
Reis, Pâmela Guimarães
Sippert, Emília Ângela
Alves, Hugo Vicentin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Chagas disease, which is caused by the flagellate parasite Trypanosoma cruzi, affects 8–10 million people in Latin America.
The disease is endemic and is characterised by acute and chronic phases that develop in the indeterminate, cardiac, and/or gastrointestinal forms.
The immune response during human T.
cruzi infection is not completely understood, despite its role in driving the development of distinct clinical manifestations of chronic infection.
Polymorphisms in genes involved in the innate and specific immune response are being widely studied in order to clarify their possible role in the occurrence or severity of disease.
Here we review the role of classic and nonclassic MHC, KIR, and cytokine host genetic factors on the infection by T.
cruzi and the clinical course of Chagas disease.
American Psychological Association (APA)
Ayo, Christiane Maria& Dalalio, Márcia Machado de Oliveira& Visentainer, Jeane Eliete Laguila& Reis, Pâmela Guimarães& Sippert, Emília Ângela& Jarduli, Luciana Ribeiro…[et al.]. 2013. Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030300
Modern Language Association (MLA)
Ayo, Christiane Maria…[et al.]. Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030300
American Medical Association (AMA)
Ayo, Christiane Maria& Dalalio, Márcia Machado de Oliveira& Visentainer, Jeane Eliete Laguila& Reis, Pâmela Guimarães& Sippert, Emília Ângela& Jarduli, Luciana Ribeiro…[et al.]. Genetic Susceptibility to Chagas Disease: An Overview about the Infection and about the Association between Disease and the Immune Response Genes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030300