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FOXP3+ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFα Agents
Joint Authors
Guidi, Luisa
Felice, Carla
Procoli, Annabella
Bonanno, Giuseppina
Martinelli, Enrica
Marzo, Manuela
Mocci, Giammarco
Pugliese, Daniela
Andrisani, Gianluca
Danese, Silvio
De Vitis, Italo
Papa, Alfredo
Rutella, Sergio
Armuzzi, A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Treg modulation has been hypothesized as one of the mechanisms by which antitumor necrosis factor α (TNFα) agents exert their action in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
However, data in IBD are still conflicting.
We evaluated CD4+CD25+FOXP3+ (Tregs) by flow cytometry in peripheral blood from 32 adult IBD patient before (T0) and after the induction of anti-TNFα therapy (T1).
Eight healthy controls (HCs) were included.
We also evaluated the number of FOXP3+ cells in the lamina propria (LP) in biopsies taken in a subset of patients and controls.
Treg frequencies were significantly increased in peripheral blood from our patients after anti-TNFα therapy compared to T0.
T1 but not T0 levels were higher than HC.
The increase was detectable only in clinical responders to the treatment.
A negative correlation was found among delta Treg levels and the age of patients or disease duration and with the activity score of Crohn’s disease (CD).
No significant differences were found in LP FOXP3+ cells.
Our data suggest the possibility that in IBD patients the treatment with anti-TNFα may affect Treg percentages and that Treg modifications may correlate with clinical response, but differently in early versus late disease.
American Psychological Association (APA)
Guidi, Luisa& Felice, Carla& Procoli, Annabella& Bonanno, Giuseppina& Martinelli, Enrica& Marzo, Manuela…[et al.]. 2013. FOXP3+ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFα Agents. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030305
Modern Language Association (MLA)
Guidi, Luisa…[et al.]. FOXP3+ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFα Agents. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030305
American Medical Association (AMA)
Guidi, Luisa& Felice, Carla& Procoli, Annabella& Bonanno, Giuseppina& Martinelli, Enrica& Marzo, Manuela…[et al.]. FOXP3+ T Regulatory Cell Modifications in Inflammatory Bowel Disease Patients Treated with Anti-TNFα Agents. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030305