Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression
Joint Authors
Jiang, Yang
Chou, Kuo-Chen
Huang, Tao
Gao, Yu-Fei
Chen, Lei
Cai, Yu-Dong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Colorectal cancer is generally categorized into the following four stages according to its development or serious degree: Dukes A, B, C, and D.
Since different stage of colorectal cancer actually corresponds to different activated region of the network, the transition of different network states may reflect its pathological changes.
In view of this, we compared the gene expressions among the colorectal cancer patients in the aforementioned four stages and obtained the early and late stage biomarkers, respectively.
Subsequently, the two kinds of biomarkers were both mapped onto the protein interaction network.
If an early biomarker and a late biomarker were close in the network and also if their expression levels were correlated in the Dukes B and C patients, then a signal propagation path from the early stage biomarker to the late one was identified.
Many transition genes in the signal propagation paths were involved with the signal transduction, cell communication, and cellular process regulation.
Some transition hubs were known as colorectal cancer genes.
The findings reported here may provide useful insights for revealing the mechanism of colorectal cancer progression at the cellular systems biology level.
American Psychological Association (APA)
Jiang, Yang& Huang, Tao& Chen, Lei& Gao, Yu-Fei& Cai, Yu-Dong& Chou, Kuo-Chen. 2013. Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030306
Modern Language Association (MLA)
Jiang, Yang…[et al.]. Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030306
American Medical Association (AMA)
Jiang, Yang& Huang, Tao& Chen, Lei& Gao, Yu-Fei& Cai, Yu-Dong& Chou, Kuo-Chen. Signal Propagation in Protein Interaction Network during Colorectal Cancer Progression. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030306