Estradiol Synthesis and Release in Cultured Female Rat Bone Marrow Stem Cells
Joint Authors
Wu, Lei
Zhang, Dalei
Lu, Xiaying
Xiong, Mingdi
Gao, Junhong
Xu, Sifan
Wang, Jinglei
Zou, Weiying
Yang, Bei
Zou, Ting
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Bone marrow stem cells (BMSCs) have the capacity to differentiate into mature cell types of multiple tissues.
Thus, they represent an alternative source for organ-specific cell replacement therapy in degenerative diseases.
In this study, we demonstrated that female rat BMSCs could differentiate into steroidogenic cells with the capacity for de novo synthesis of Estradiol-17β (E2) under high glucose culture conditions with or without retinoic acid (RA).
The cultured BMSCs could express the mRNA and protein for P450arom, the enzyme responsible for estrogen biosynthesis.
Moreover, radioimmunoassay revealed that BMSCs cultured in the present culture system produced and secreted significant amounts of testosterone, androstenedione, and E2.
In addition, RA promoted E2 secretion but did not affect the levels of androgen.
These results indicate that BMSCs can synthesize and release E2 and may contribute to autologous transplantation therapy for estrogen deficiency.
American Psychological Association (APA)
Zhang, Dalei& Yang, Bei& Zou, Weiying& Lu, Xiaying& Xiong, Mingdi& Wu, Lei…[et al.]. 2012. Estradiol Synthesis and Release in Cultured Female Rat Bone Marrow Stem Cells. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030342
Modern Language Association (MLA)
Zhang, Dalei…[et al.]. Estradiol Synthesis and Release in Cultured Female Rat Bone Marrow Stem Cells. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030342
American Medical Association (AMA)
Zhang, Dalei& Yang, Bei& Zou, Weiying& Lu, Xiaying& Xiong, Mingdi& Wu, Lei…[et al.]. Estradiol Synthesis and Release in Cultured Female Rat Bone Marrow Stem Cells. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030342