Molecular Characterization of TP53 Gene in Human Populations Exposed to Low-Dose Ionizing Radiation
Joint Authors
Burbano, Rommel Rodríguez
Brasil-Costa, Igor
Alencar, Dayse O.
Raiol-Moraes, Milene
Pessoa, Igor A.
Brito, Alexandre W. M.
Jati, Schneyder R.
Santos, Sidney E. B.
Ribeiro-dos-Santos, Ândrea K. C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ionizing radiation, such as that emitted by uranium, may cause mutations and consequently lead to neoplasia in human cells.
The TP53 gene acts to maintain genomic integrity and constitutes an important biomarker of susceptibility.
The present study investigated the main alterations observed in exons 4, 5, 6, 7, and 8 of the TP53 gene and adjacent introns in Amazonian populations exposed to radioactivity.
Samples were collected from 163 individuals.
Occurrence of the following alterations was observed: (i) a missense exchange in exon 4 (Arg72Pro); (ii) 2 synonymous exchanges, 1 in exon 5 (His179His), and another in exon 6 (Arg213Arg); (iii) 4 intronic exchanges, 3 in intron 7 (C → T at position 13.436; C → T at position 13.491; T → G at position 13.511) and 1 in intron 8 (T → G at position 13.958).
Alteration of codon 72 was found to be an important risk factor for cancer development (P=0.024; OR=6.48; CI: 1.29–32.64) when adjusted for age and smoking.
Thus, TP53 gene may be an important biomarker for carcinogenesis susceptibility in human populations exposed to ionizing radiation.
American Psychological Association (APA)
Brasil-Costa, Igor& Alencar, Dayse O.& Raiol-Moraes, Milene& Pessoa, Igor A.& Brito, Alexandre W. M.& Jati, Schneyder R.…[et al.]. 2013. Molecular Characterization of TP53 Gene in Human Populations Exposed to Low-Dose Ionizing Radiation. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030343
Modern Language Association (MLA)
Brasil-Costa, Igor…[et al.]. Molecular Characterization of TP53 Gene in Human Populations Exposed to Low-Dose Ionizing Radiation. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030343
American Medical Association (AMA)
Brasil-Costa, Igor& Alencar, Dayse O.& Raiol-Moraes, Milene& Pessoa, Igor A.& Brito, Alexandre W. M.& Jati, Schneyder R.…[et al.]. Molecular Characterization of TP53 Gene in Human Populations Exposed to Low-Dose Ionizing Radiation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030343