Familial Aggregation of Metabolic Syndrome Indicators in Portuguese Families
Joint Authors
Gomes, T. N.
Maia, J. A.
Trégouet, D.-A.
Katzmarzyk, P. T.
Santos, F. K.
Santos, D. M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Family studies are well suited to investigate the genetic architecture underlying the metabolic syndrome (MetS).
The purposes of this paper were (i) to estimate heritabilities for each of the MetS indicators, and (ii) to test the significance of familial intratrait and cross-trait correlations in MetS markers.
Methods and Results.
This study included 1,363 individuals from 515 Portuguese families in which five MetS components, including waist circumference (WC), blood pressure (BP), HDL-cholesterol, triglycerides (TG), and glucose (GLU), were measured.
Intratrait and cross-trait familial correlations of these five components were estimated using Generalized Estimating Equations.
Each MetS component was significantly heritable (h2 ranged from 0.12 to 0.60) and exhibited strong familial resemblance with correlations between biological relatives of similar magnitude to those observed between spouses.
With respect to cross-trait correlations, familial resemblance was very weak except for the HDL-TG pair.
Conclusions.
The present findings confirm the idea of familial aggregation in MetS traits.
Spousal correlations were, in general, of the same magnitude as the biological relatives' correlations suggesting that most of the phenotypic variance in MetS traits could be explained by shared environment.
American Psychological Association (APA)
Santos, D. M.& Katzmarzyk, P. T.& Trégouet, D.-A.& Gomes, T. N.& Santos, F. K.& Maia, J. A.. 2013. Familial Aggregation of Metabolic Syndrome Indicators in Portuguese Families. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030359
Modern Language Association (MLA)
Santos, D. M.…[et al.]. Familial Aggregation of Metabolic Syndrome Indicators in Portuguese Families. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030359
American Medical Association (AMA)
Santos, D. M.& Katzmarzyk, P. T.& Trégouet, D.-A.& Gomes, T. N.& Santos, F. K.& Maia, J. A.. Familial Aggregation of Metabolic Syndrome Indicators in Portuguese Families. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030359