Taenia crassiceps Infection Does Not Influence the Development of Experimental Rheumatoid Arthritis
Joint Authors
Ortiz-Flores, Aaxin M.
Ledesma-Soto, Yadira
Calleja, Elsa A.
Juárez, Imelda
Terrazas, Luis I.
Rodríguez-Sosa, Miriam
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It was previously reported by our group that infection with Taenia crassiceps reduces incidence and severity of inflammatory and autoimmune experimental diseases like type 1 diabetes and experimental autoimmune encephalomyelitis.
In this research, we set out to study whether infection with T.
crassiceps would affect the development of experimental rheumatoid arthritis (RA).
We found that mice infected with the parasite and induced with experimental RA showed similar clinical scores as the noninfected experimental RA group; systemic cytokines were not affected while anti-CII Abs were higher in the infected group.
Histological evaluation showed damage in both infected and noninfected experimental RA-induced groups and although some surface molecules such as PDL-2 and MR which are associated with immunomodulatory mechanisms were upregulated in the infected and RA-induced group as compared to the noninfected RA group, they did not exert any changes in the outcome of experimental RA.
Thus, we determined that infection with T.
crassiceps does not influence the outcome of experimental RA.
American Psychological Association (APA)
Ortiz-Flores, Aaxin M.& Ledesma-Soto, Yadira& Calleja, Elsa A.& Rodríguez-Sosa, Miriam& Juárez, Imelda& Terrazas, Luis I.. 2012. Taenia crassiceps Infection Does Not Influence the Development of Experimental Rheumatoid Arthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030366
Modern Language Association (MLA)
Ortiz-Flores, Aaxin M.…[et al.]. Taenia crassiceps Infection Does Not Influence the Development of Experimental Rheumatoid Arthritis. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030366
American Medical Association (AMA)
Ortiz-Flores, Aaxin M.& Ledesma-Soto, Yadira& Calleja, Elsa A.& Rodríguez-Sosa, Miriam& Juárez, Imelda& Terrazas, Luis I.. Taenia crassiceps Infection Does Not Influence the Development of Experimental Rheumatoid Arthritis. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030366