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Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients
Joint Authors
Gupta, S. K.
Singh, Kanhaiya
Singh, Vivek Kumar
Agrawal, Neeraj K.
Singh, Kiran
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Toll-Like receptor 4 (TLR4) plays an important role in immunity, tissue repair, and regeneration.
The objective of the present work was to evaluate the association of TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs11536858 (merged into rs10759931), rs1927911, and rs1927914 with increased diabetic foot ulcer (DFU) risk in patients with type 2 diabetes mellitus (T2DM).
PCR-RFLP was used for genotyping TLR4 SNPs in 125 T2DM patients with DFU and 130 controls.
The haplotypes and linkage disequilibrium between the SNPs were determined using Haploview software.
Multivariate linear regression (MLR) and artificial neural network (ANN) modeling was done to observe their predictability for the risk of DFU in T2DM patients.
Risk genotypes of all SNPs except rs1927914 were significantly associated with DFU.
Haplotype ACATC (P value = 9.3E-5) showed strong association with DFU risk.
Two haplotypes ATATC (P value = 0.0119) and ATGTT (P value = 0.0087) were found to be protective against DFU.
In conclusion TLR4 SNPs and their haplotypes may increase the risk of impairment of wound healing in T2DM patients.
ANN model (83%) is found to be better than the MLR model (76%) and can be used as a tool for the DFU risk assessment in T2DM patients.
American Psychological Association (APA)
Singh, Kanhaiya& Singh, Vivek Kumar& Agrawal, Neeraj K.& Gupta, S. K.& Singh, Kiran. 2013. Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030378
Modern Language Association (MLA)
Singh, Kanhaiya…[et al.]. Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030378
American Medical Association (AMA)
Singh, Kanhaiya& Singh, Vivek Kumar& Agrawal, Neeraj K.& Gupta, S. K.& Singh, Kiran. Association of Toll-Like Receptor 4 Polymorphisms with Diabetic Foot Ulcers and Application of Artificial Neural Network in DFU Risk Assessment in Type 2 Diabetes Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030378