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Differential Regulation of Ferritin Subunits and Iron Transport Proteins: An Effect of Targeted Hepatic X-Irradiation
Joint Authors
Christiansen, Hans
Malik, Ihtzaz A.
Naz, Naila
Ahmad, Shakil
Cameron, Silke
Moriconi, Federico
Rave-Fränk, Margret
Hess, Clemens Friedrich
Ramadori, Giuliano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The current study aimed to investigate radiation-induced regulation of iron proteins including ferritin subunits in rats.
Rat livers were selectively irradiated in vivo at 25 Gy.
This dose can be used to model radiation effects to the liver without inducing overt radiation-induced liver disease.
Sham-irradiated rats served as controls.
Isolated hepatocytes were irradiated at 8 Gy.
Ferritin light polypeptide (FTL) was detectable in the serum of sham-irradiated rats with an increase after irradiation.
Liver irradiation increased hepatic protein expression of both ferritin subunits.
A rather early increase (3 h) was observed for hepatic TfR1 and Fpn-1 followed by a decrease at 12 h.
The increase in TfR2 persisted over the observed time.
Parallel to the elevation of AST levels, a significant increase (24 h) in hepatic iron content was measured.
Complete blood count analysis showed a significant decrease in leukocyte number with an early increase in neutrophil granulocytes and a decrease in lymphocytes.
In vitro, a significant increase in ferritin subunits at mRNA level was detected after irradiation which was further induced with a combination treatment of irradiation and acute phase cytokine.
Irradiation can directly alter the expression of ferritin subunits and this response can be strongly influenced by radiation-induced proinflammatory cytokines.
FTL can be used as a serum marker for early phase radiation-induced liver damage.
American Psychological Association (APA)
Naz, Naila& Ahmad, Shakil& Cameron, Silke& Moriconi, Federico& Rave-Fränk, Margret& Christiansen, Hans…[et al.]. 2013. Differential Regulation of Ferritin Subunits and Iron Transport Proteins: An Effect of Targeted Hepatic X-Irradiation. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030430
Modern Language Association (MLA)
Naz, Naila…[et al.]. Differential Regulation of Ferritin Subunits and Iron Transport Proteins: An Effect of Targeted Hepatic X-Irradiation. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030430
American Medical Association (AMA)
Naz, Naila& Ahmad, Shakil& Cameron, Silke& Moriconi, Federico& Rave-Fränk, Margret& Christiansen, Hans…[et al.]. Differential Regulation of Ferritin Subunits and Iron Transport Proteins: An Effect of Targeted Hepatic X-Irradiation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030430