Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments
Joint Authors
Hamamah, Samir
Dechaud, Hervé
Ferrières, Alice
Assou, Said
Haouzi, Delphine
Gala, Anna
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In in vitro fertilization cycles, both HP-hMG and rFSH gonadotropin treatments are widely used to control human follicle development.
The objectives of this study are (i) to characterize and compare gene expression profiles in cumulus cells (CCs) of periovulatory follicles obtained from patients stimulated with HP-hMG or rFSH in a GnRH antagonist cycle and (ii) to examine their relationship with in vitro embryo development, using Human Genome U133 Plus 2.0 microarrays.
Genes that were upregulated in HP-hMG-treated CCs are involved in lipid metabolism (GM2A) and cell-to-cell interactions (GJA5).
Conversely, genes upregulated in rFSH-treated CCs are implicated in cell assembly and organization (COL1A1 and COL3A1).
Interestingly, some genes specific to each gonadotropin treatment (NPY1R and GM2A for HP-hMG; GREM1 and OSBPL6 for rFSH) were associated with day 3 embryo quality and blastocyst grade at day 5, while others (STC2 and PTX3) were related to in vitro embryo quality in both gonadotropin treatments.
These genes may prove valuable as biomarkers of in vitro embryo quality.
American Psychological Association (APA)
Assou, Said& Haouzi, Delphine& Dechaud, Hervé& Gala, Anna& Ferrières, Alice& Hamamah, Samir. 2013. Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030433
Modern Language Association (MLA)
Assou, Said…[et al.]. Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030433
American Medical Association (AMA)
Assou, Said& Haouzi, Delphine& Dechaud, Hervé& Gala, Anna& Ferrières, Alice& Hamamah, Samir. Comparative Gene Expression Profiling in Human Cumulus Cells according to Ovarian Gonadotropin Treatments. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030433