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Pharmacokinetic Properties and Systemic Safety of Vancomycin-Impregnated Cancellous Bone Grafts in the Treatment of Spondylodiscitis
Joint Authors
Anagnostakos, Konstantinos
Koch, Katrin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of the present study was to investigate the local pharmacokinetic properties and the systemic safety of vancomycin-impregnated cancellous bone grafts in the treatment of spondylodiscitis.
Between 2010 and 2012, 8 patients (5 females, 3 males, mean age 68.75 y.) were treated with this method.
Local vancomycin concentrations reached median values of 179 µg/mL (maximum 365 µg/mL) on day 1, decreasing to 98 µg/mL on day 3.
The urine vancomycin concentrations showed similar pharmacokinetic properties as those locally determined.
On day 1, median values were at 28.05 µg/mL (maximum 287 µg/mL).
All serum vancomycin concentrations were in all cases and on every day below <2 µg/mL.
The median serum creatinine values were preoperatively 0.87 mg/dL, followed by 0.625 mg/dL, 0.705 mg/dL, and 0.835 mg/dL on day 7, 14, and 28, respectively.
No cases of ototoxicity could be observed.
At a mean follow-up of 16.5 [4–36] months no cases of reinfections or persistent infections could be seen.
In conclusion, the implantation of vancomycin-loaded cancellous bone grafts is an effective option in the treatment of spondylodiscitis with a high infection eradication rate and no risk of any systemic toxicity.
The pharmacokinetic properties can be easily monitored locally, in the urine and the serum.
American Psychological Association (APA)
Anagnostakos, Konstantinos& Koch, Katrin. 2013. Pharmacokinetic Properties and Systemic Safety of Vancomycin-Impregnated Cancellous Bone Grafts in the Treatment of Spondylodiscitis. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030435
Modern Language Association (MLA)
Anagnostakos, Konstantinos& Koch, Katrin. Pharmacokinetic Properties and Systemic Safety of Vancomycin-Impregnated Cancellous Bone Grafts in the Treatment of Spondylodiscitis. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030435
American Medical Association (AMA)
Anagnostakos, Konstantinos& Koch, Katrin. Pharmacokinetic Properties and Systemic Safety of Vancomycin-Impregnated Cancellous Bone Grafts in the Treatment of Spondylodiscitis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030435