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Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer
Joint Authors
Teixeira, Frederico
Parada, Belmiro
Sereno, José
Cerejo, Raquel
Xavier-Cunha, Maria
Neto, Paula
Mota, Alfredo
Garrido, Patrícia
Reis, Flávio
Figueiredo, Arnaldo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Omega-3 (ω-3) fatty acids have been tested on prevention and treatment of several cancer types, but the efficacy on “in vivo” bladder cancer has not been analyzed yet.
This study aimed at evaluating the chemopreventive efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) mixture in an animal model of bladder cancer.
Forty-four male Wistar rats were divided into 4 groups during a 20-week protocol: control; carcinogen—N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN); ω-3 (DHA + EPA); and ω-3 + BBN.
BBN and ω-3 were given during the initial 8 weeks.
At week 20 blood and bladder were collected and checked for the presence of urothelium lesions and tumors, markers of inflammation, proliferation, and redox status.
Incidence of bladder carcinoma was, control (0%), ω-3 (0%), BBN (65%), and ω-3 + BBN (62.5%).
The ω-3 + BBN group had no infiltrative tumors or carcinoma in situ, and tumor volume was significantly reduced compared to the BBN (0.9 ± 0.1 mm3 versus 112.5 ± 6.4 mm3).
Also, it showed a reduced MDA/TAS ratio and BBN-induced serum CRP, TGF-β1, and CD31 were prevented.
In conclusion, omega-3 fatty acids inhibit the development of premalignant and malignant lesions in a rat model of bladder cancer, which might be due to anti-inflammatory, antioxidant, anti-proliferative, and anti-angiogenic properties.
American Psychological Association (APA)
Parada, Belmiro& Reis, Flávio& Cerejo, Raquel& Garrido, Patrícia& Sereno, José& Xavier-Cunha, Maria…[et al.]. 2013. Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030442
Modern Language Association (MLA)
Parada, Belmiro…[et al.]. Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030442
American Medical Association (AMA)
Parada, Belmiro& Reis, Flávio& Cerejo, Raquel& Garrido, Patrícia& Sereno, José& Xavier-Cunha, Maria…[et al.]. Omega-3 Fatty Acids Inhibit Tumor Growth in a Rat Model of Bladder Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030442