The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats
Joint Authors
Ekici, Hüsamettin
Çınar, Miyase
Atmaca, Nurgül
Yıldırım, Ebru
Baydan, Emine
Kanbur, Murat
Kul, Oğuz
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study investigated the effect of chlorpyrifos on thoracic aorta and on the level of NO in plasma and aorta.
The effect of chlorpyrifos on thoracic aorta in organ bath was determined in 10 rats.
Another 45 rats were assigned to 3 groups with 15 rats each: control group 1 received distilled water, control group 2 was given corn oil, and the last group was given 13.5 mg/kg chlorpyrifos dissolved in corn oil every other day for 8 weeks orally.
Chlorpyrifos (10−10 M–10−5 M) showed no effect on isolated thoracic aorta.
Plasma AChE activity was decreased, while LDH, ALT, GGT, and AST activities were increased in chlorpyrifos group compared to control groups.
Plasma NO level was increased in chlorpyrifos group compared to control groups.
iNOS expression was present in all groups in the cytoplasm of the endothelia and in the smooth muscle cells of aorta.
According to semiquantitative histomorphological analysis, iNOS immunopositive reactions were seen in the decreasing order in chlorpyrifos, control 2, and control 1 groups.
eNOS immunopositive reactions were observed in the endothelial cell cytoplasm, rarely in the subintimal layer, and the smooth muscle cells of aorta.
There were no differences among the groups in terms of eNOS immunostaining.
In conclusion, chlorpyrifos induced NO production in aorta following an increase in NOS expression.
American Psychological Association (APA)
Yıldırım, Ebru& Baydan, Emine& Kanbur, Murat& Kul, Oğuz& Çınar, Miyase& Ekici, Hüsamettin…[et al.]. 2013. The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030453
Modern Language Association (MLA)
Yıldırım, Ebru…[et al.]. The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030453
American Medical Association (AMA)
Yıldırım, Ebru& Baydan, Emine& Kanbur, Murat& Kul, Oğuz& Çınar, Miyase& Ekici, Hüsamettin…[et al.]. The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030453