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Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice
Joint Authors
Shioda, Seiji
Tsumuraya, Tomomi
Song, Dandan
Kiriyama, Keisuke
Satoh, Kazue
Shimizu, Ai
Aruga, Tohru
Miyamoto, Kazuyuki
Dohi, Kenji
Ohtaki, Hirokazu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Traumatic brain injury (TBI) is a major cause of death and disability in young people.
No effective therapy is available to ameliorate its damaging effects.
Our aim was to investigate the optimal therapeutic time window of edaravone, a free radical scavenger which is currently used in Japan.
We also determined the temporal profile of reactive oxygen species (ROS) production, oxidative stress, and neuronal death.
Male C57Bl/6 mice were subjected to a controlled cortical impact (CCI).
Edaravone (3.0 mg/kg), or vehicle, was administered intravenously at 0, 3, or 6 hours following CCI.
The production of superoxide radicals (O2∙-) as a marker of ROS, of nitrotyrosine (NT) as an indicator of oxidative stress, and neuronal death were measured for 24 hours following CCI.
Superoxide radical production was clearly evident 3 hours after CCI, with oxidative stress and neuronal cell death becoming apparent after 6 hours.
Edaravone administration after CCI resulted in a significant reduction in the injury volume and oxidative stress, particularly at the 3-hour time point.
Moreover, the greatest decrease in O2∙- levels was observed when edaravone was administered 3 hours following CCI.
These findings suggest that edaravone could prove clinically useful to ameliorate the devastating effects of TBI.
American Psychological Association (APA)
Miyamoto, Kazuyuki& Ohtaki, Hirokazu& Dohi, Kenji& Song, Dandan& Kiriyama, Keisuke& Satoh, Kazue…[et al.]. 2013. Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030455
Modern Language Association (MLA)
Miyamoto, Kazuyuki…[et al.]. Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030455
American Medical Association (AMA)
Miyamoto, Kazuyuki& Ohtaki, Hirokazu& Dohi, Kenji& Song, Dandan& Kiriyama, Keisuke& Satoh, Kazue…[et al.]. Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030455