CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors
Joint Authors
Nam-Cha, S. H.
Serrano-Vargas, R.
Escario, E.
Azaña, J. M.
Calero-Oliver, R.
Martín, A. G.
Poblet, E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Expression of human CD133 (human prominin-1) in cancer cells has been postulated to be a marker of stemness and is considered as a putative marker of cancer stem cells (CSCs).
We designed a study to describe the expression pattern of CD133 in normal skin and in epithelial cutaneous neoplasms.
Methods.
The CD133 immunohistochemical expression of forty-three eccrine and apocrine tumors was compared to that observed in other epithelial tumors of the skin.
In addition, flow cytometry was used to detect the CD133 expression of four epithelial skin neoplasms, including one porocarcinoma.
Results.
CD133 immunoreactivity at the apical or at the apicolateral surface of cells forming glandular structures was observed.
Cells from solid areas of benign or malignant tumors were not stained.
The porocarcinoma derived culture cells showed a 22% of CD133 positive cells using flow cytometry, while squamous cell carcinoma cultures contained less than 0.1%.
Conclusions.
These observations indicate that CD133 is a specific marker of glandular differentiation that could be included in the diagnostic panel of cutaneous tumors with possible eccrine or apocrine differentiation.
However, the use of CD133 expression as a marker of CSCs should be interpreted with caution in experiments of skin.
American Psychological Association (APA)
Nam-Cha, S. H.& Serrano-Vargas, R.& Escario, E.& Azaña, J. M.& Calero-Oliver, R.& Martín, A. G.…[et al.]. 2013. CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030484
Modern Language Association (MLA)
Nam-Cha, S. H.…[et al.]. CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030484
American Medical Association (AMA)
Nam-Cha, S. H.& Serrano-Vargas, R.& Escario, E.& Azaña, J. M.& Calero-Oliver, R.& Martín, A. G.…[et al.]. CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030484