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In Vitro Antibacterial and Antibiofilm Activities of Chlorogenic Acid against Clinical Isolates of Stenotrophomonas maltophilia including the TrimethoprimSulfamethoxazole Resistant Strain
Joint Authors
Thomas, Renjan
van Belkum, Alex
Neela, Vasanthakumari
Karunanidhi, Arunkumar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The in vitro antibacterial and antibiofilm activity of chlorogenic acid against clinical isolates of Stenotrophomonas maltophilia was investigated through disk diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time-kill and biofilm assays.
A total of 9 clinical S.
maltophilia isolates including one isolate resistant to trimethoprim/sulfamethoxazole (TMP/SMX) were tested.
The inhibition zone sizes for the isolates ranged from 17 to 29 mm, while the MIC and MBC values ranged from 8 to 16 μg mL−1 and 16 to 32 μg mL−1.
Chlorogenic acid appeared to be strongly bactericidal at 4x MIC, with a 2-log reduction in viable bacteria at 10 h.
In vitro antibiofilm testing showed a 4-fold reduction in biofilm viability at 4x MIC compared to 1x MIC values (0.085<0.397 A 490 nm) of chlorogenic acid.
The data from this study support the notion that the chlorogenic acid has promising in vitro antibacterial and antibiofilm activities against S.
maltophilia.
American Psychological Association (APA)
Karunanidhi, Arunkumar& Thomas, Renjan& van Belkum, Alex& Neela, Vasanthakumari. 2012. In Vitro Antibacterial and Antibiofilm Activities of Chlorogenic Acid against Clinical Isolates of Stenotrophomonas maltophilia including the TrimethoprimSulfamethoxazole Resistant Strain. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030503
Modern Language Association (MLA)
Karunanidhi, Arunkumar…[et al.]. In Vitro Antibacterial and Antibiofilm Activities of Chlorogenic Acid against Clinical Isolates of Stenotrophomonas maltophilia including the TrimethoprimSulfamethoxazole Resistant Strain. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030503
American Medical Association (AMA)
Karunanidhi, Arunkumar& Thomas, Renjan& van Belkum, Alex& Neela, Vasanthakumari. In Vitro Antibacterial and Antibiofilm Activities of Chlorogenic Acid against Clinical Isolates of Stenotrophomonas maltophilia including the TrimethoprimSulfamethoxazole Resistant Strain. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030503