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Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans
Joint Authors
Lee, Yeon-Su
Lee, Sang-Jin
Joung, Jae Young
Yoon, Hyekyoung
Kim, Jeong Eun
Park, Weon Seo
Seo, Ho Kyung
Chung, Jinsoo
Hwang, Jung-Ah
Hong, Seung-Hyun
Park, Sohee
Kim, Jeongseon
Lee, Kang Hyun
Nam, Seungyoon
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
To assess if the variants of (R)-alpha-methyl-CoA racemase (AMACR) gene would be associated with the risk of sporadic prostate cancer in ethnically homogenous Koreans.
Materials and Methods.
We enrolled 194 patients with prostate cancer and 169 healthy controls.
A total of 17 single nucleotide polymorphisms of the AMACR gene were selected.
The distribution of each genotype and haplotype was analyzed and their association with the incidence of prostate cancer was evaluated.
Further, we detected AMACR expression in tumor with immunohistochemistry and analyzed its association with genotype regarding prostate cancer risk.
Results.
AG or GG genotype of rs2278008 (E277K) tended to lower prostate cancer risk.
The minor G allele was found to be a significant allele that decreased the risk of prostate cancer (adjusted OR, 0.57; 95% CI, 0.35–0.93, P value = 0.025).
In patients expression AMACR, AG or GG genotype was also significant genotype in terms of prostate cancer risk (adjusted OR, 0.47; 95% CI, 0.26–0.87, P value = 0.017).
Further, [GGCGG] haplotype consisted of five coding SNPs of rs2278008, rs34677, rs2287939, rs10941112, and rs3195676 which decreased the risk of prostate cancer (P value = 0.047).
Conclusions.
Genetic variations of AMACR are associated with the risk of sporadic prostate cancer that underwent radical prostatectomy in Koreans.
American Psychological Association (APA)
Lee, Sang-Jin& Joung, Jae Young& Yoon, Hyekyoung& Kim, Jeong Eun& Park, Weon Seo& Seo, Ho Kyung…[et al.]. 2013. Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030504
Modern Language Association (MLA)
Lee, Sang-Jin…[et al.]. Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030504
American Medical Association (AMA)
Lee, Sang-Jin& Joung, Jae Young& Yoon, Hyekyoung& Kim, Jeong Eun& Park, Weon Seo& Seo, Ho Kyung…[et al.]. Genetic Variations of α-Methylacyl-CoA Racemase Are Associated with Sporadic Prostate Cancer Risk in Ethnically Homogenous Koreans. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030504