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IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
Joint Authors
Cruz, Miguel
Estrada-Velasco, B. I.
Martínez-Nava, G. A.
Gomez-Zamudio, J.
Burguete-García, A. I.
Madrid-Marina, V.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
We aimed to explore the association between polymorphisms of IRS1 (rs1801278), TCF7L2 (rs7903146 and rs12255372), ADRB1 (rs1801253), PPARG (rs1801282), and HHEX (rs5015480) genes with atherogenic risk (AI = Total cholesterol/HDL) in MetS, T2D, and healthy populations from the Mexican Social Security Institute.
Methodology and Results.
Four hundred thirty-five MetS, 517 T2D, and 547 healthy individuals were selected.
The association between the SNPs and the atherogenic index was evaluated by multiple linear regression and multinomial logistic regression models.
The ADRB1 gene showed a statistically significant association with high-risk atherogenic index, OR=2.94 (IC 95% 1.64–5.24; P<0.0001) for the Arg/Gly variant, under the dominant model an OR=2.96 (IC 95% 1.67–5.25; P<0.0001), and under the Log additive model an OR=2.52 (IC 95% 1.54–4.15; P<0.0001).
Conclusions.
The Arg389Gly polymorphism of the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index.
American Psychological Association (APA)
Estrada-Velasco, B. I.& Cruz, Miguel& Madrid-Marina, V.& Martínez-Nava, G. A.& Gomez-Zamudio, J.& Burguete-García, A. I.. 2013. IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030505
Modern Language Association (MLA)
Estrada-Velasco, B. I.…[et al.]. IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030505
American Medical Association (AMA)
Estrada-Velasco, B. I.& Cruz, Miguel& Madrid-Marina, V.& Martínez-Nava, G. A.& Gomez-Zamudio, J.& Burguete-García, A. I.. IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030505