Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome
Joint Authors
Fernandes-Cerqueira, Cátia
Sampaio-Maia, Benedita
Quelhas-Santos, Janete
Moreira-Rodrigues, Mónica
Simões-Silva, Liliana
Blazquez-Medela, Ana M.
Martinez-Salgado, C.
Pestana, Manuel
López-Novoa, José M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The edema formation in nephrotic syndrome (NS) is associated with a blunted response to atrial natriuretic peptide (ANP).
The natriuretic effects of ANP have been related to renal dopamine D1-receptors (D1R).
We examined the interaction between ANP and renal D1R in rats with puromycin aminonucleoside-induced NS (PAN-NS).
Urinary sodium, cyclic guanosine monophosphate (cGMP) excretion, and D1R protein expression and localization in renal tubules were evaluated in PAN-NS and control rats before and during volume expansion (VE).
The effects of zaprinast (phosphodiesterase type 5 inhibitor), alone or in combination with Sch-23390 (D1R antagonist), were examined in both groups.
The increased natriuresis and urinary cGMP excretion evoked by acute VE were blunted in PAN-NS despite increased levels of circulating ANP.
This was accompanied in PAN-NS by a marked decrease of D1R expression in the renal tubules.
Infusion of zaprinast in PAN-NS resulted in increased urinary excretion of cGMP and sodium to similar levels of control rats and increased expression of D1R in the plasma membrane of renal tubular cells.
Combined administration of Sch-23390 and zaprinast prevented natriuresis and increased cGMP excretion induced by zaprinast alone.
We conclude that D1R may play a major role in the ANP resistance observed in PAN-NS.
American Psychological Association (APA)
Fernandes-Cerqueira, Cátia& Sampaio-Maia, Benedita& Quelhas-Santos, Janete& Moreira-Rodrigues, Mónica& Simões-Silva, Liliana& Blazquez-Medela, Ana M.…[et al.]. 2013. Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030508
Modern Language Association (MLA)
Fernandes-Cerqueira, Cátia…[et al.]. Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030508
American Medical Association (AMA)
Fernandes-Cerqueira, Cátia& Sampaio-Maia, Benedita& Quelhas-Santos, Janete& Moreira-Rodrigues, Mónica& Simões-Silva, Liliana& Blazquez-Medela, Ana M.…[et al.]. Concerted Action of ANP and Dopamine D1-Receptor to Regulate Sodium Homeostasis in Nephrotic Syndrome. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030508