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The Treatment Outcome and Radiation-Induced Toxicity for Patients with Head and Neck Carcinoma in the IMRT Era: A Systematic Review with Dosimetric and Clinical Parameters
Joint Authors
Kelekis, Nikolaos
Thalassinou, Stella
Zygogianni, Anna
Kouvaris, John
Antypas, Christos
Kouloulias, Vassilis
Efstathopoulos, Efstathios P.
Platoni, Kalliopi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A descriptive analysis was made in terms of the related radiation induced acute and late mucositis and xerostomia along with survival and tumor control rates (significance level at 0.016, bonferroni correction), for irradiation in head and neck carcinomas with either 2D Radiation Therapy (2DRT) and 3D conformal (3DCRT) or Intensity Modulated Radiation Therapy (IMRT).
The mean score of grade > II xerostomia for IMRT versus 2-3D RT was 0.31 ± 0.23 and 0.56 ± 0.23, respectively (Mann Whitney, P<0.001).
The parotid-dose for IMRT versus 2-3D RT was 29.56 ± 5.45 and 50.73 ± 6.79, respectively (Mann Whitney, P=0.016).
The reported mean parotid-gland doses were significantly correlated with late xerostomia (spearman test, rho = 0.5013, P<0.001).
A trend was noted for the superiority of IMRT concerning the acute oral mucositis.
The 3-year overall survival for either IMRT or 2-3DRT was 89.5% and 82.7%, respectively (P=0.026, Kruskal-Wallis test).
The mean 3-year locoregional control rate was 83.6% (range: 70–97%) and 74.4 (range: 61–82%), respectively (P=0.025, Kruskal-Wallis).
In conclusion, no significant differences in terms of locoregional control, overall survival and acute mucositis could be noted, while late xerostomia is definitely higher in 2-3D RT versus IMRT.
Patients with head and neck carcinoma should be referred preferably to IMRT techniques.
American Psychological Association (APA)
Kouloulias, Vassilis& Thalassinou, Stella& Platoni, Kalliopi& Zygogianni, Anna& Kouvaris, John& Antypas, Christos…[et al.]. 2013. The Treatment Outcome and Radiation-Induced Toxicity for Patients with Head and Neck Carcinoma in the IMRT Era: A Systematic Review with Dosimetric and Clinical Parameters. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030510
Modern Language Association (MLA)
Kouloulias, Vassilis…[et al.]. The Treatment Outcome and Radiation-Induced Toxicity for Patients with Head and Neck Carcinoma in the IMRT Era: A Systematic Review with Dosimetric and Clinical Parameters. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030510
American Medical Association (AMA)
Kouloulias, Vassilis& Thalassinou, Stella& Platoni, Kalliopi& Zygogianni, Anna& Kouvaris, John& Antypas, Christos…[et al.]. The Treatment Outcome and Radiation-Induced Toxicity for Patients with Head and Neck Carcinoma in the IMRT Era: A Systematic Review with Dosimetric and Clinical Parameters. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030510