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EndostatinCollagen XVIII Is Increased in Cerebrospinal Fluid after Severe Traumatic Brain Injury
Joint Authors
Xue, Li-Xia
Chen, Shi-Wen
Gao, Wen-Wei
Ju, Shi-Ming
Guo, Yan
Cao, He-Li
Chen, Hao
Tian, Heng-Li
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent studies have suggested that endogenous angiogenesis inhibitor endostatin/collagen XVIII might play an important role in the secondary brain injury following traumatic brain injury (TBI).
In this study, we measured endostatin/collagen XVIII concentrations serially for 1 week after hospitalization by using the enzyme-linked immunosorbent assay method in the cerebrospinal fluid (CSF) of 30 patients with TBI and a Glasgow Coma Scale (GCS) score of 8 or less on admission.
There was a significant trend toward increased CSF levels of endostatin after TBI versus control from 72 h after injury.
In patients with GCS score of 3–5, CSF endostatin concentration was substantially higher at 72 h after injury than that in patients with GCS score of 6–8 (P<0.05) and peaked rapidly at day 5 after injury, but decreased thereafter.
The CSF endostatin concentration in 12 patients with an unfavorable outcome was significantly higher than that in 18 patients with a favorable outcome at day 5 (P=0.043) and day 7 (P=0.005) after trauma.
Receiver operating characteristic curve analysis suggested a reliable operating point for the 7-day CSF endostatin concentration predicting poor prognosis to be 67.29 pg/mL.
Our preliminary findings provide new evidence that endostatin/collagen XVIII concentration in the CSF increases substantially in patients with sTBI.
Its dynamic change may have some clinical significance on the judgment of brain injury severity and the assessment of prognosis.
This trial is registered with the ClinicalTrials.gov Identifier: NCT01846546.
American Psychological Association (APA)
Chen, Hao& Xue, Li-Xia& Cao, He-Li& Chen, Shi-Wen& Guo, Yan& Gao, Wen-Wei…[et al.]. 2013. EndostatinCollagen XVIII Is Increased in Cerebrospinal Fluid after Severe Traumatic Brain Injury. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030512
Modern Language Association (MLA)
Chen, Hao…[et al.]. EndostatinCollagen XVIII Is Increased in Cerebrospinal Fluid after Severe Traumatic Brain Injury. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030512
American Medical Association (AMA)
Chen, Hao& Xue, Li-Xia& Cao, He-Li& Chen, Shi-Wen& Guo, Yan& Gao, Wen-Wei…[et al.]. EndostatinCollagen XVIII Is Increased in Cerebrospinal Fluid after Severe Traumatic Brain Injury. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030512