Androgen Signaling Disruption during Fetal and Postnatal Development Affects Androgen Receptor and Connexin 43 Expression and Distribution in Adult Boar Prostate

Joint Authors

Hejmej, Anna
Kotula-Balak, Malgorzata
Lydka-Zarzycka, Marta
Górowska, Ewelina
Zając, Justyna
Chojnacka, Katarzyna
Bilinska, Barbara

Source

BioMed Research International

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-17

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Medicine

Abstract EN

To date, limited knowledge exists regarding the role of the androgen signaling during specific periods of development in the regulation of androgen receptor (AR) and connexin 43 (Cx43) in adult prostate.

Therefore, in this study we examined mRNA and protein expression, and tissue distribution of AR and Cx43 in adult boar prostates following fetal (GD20), neonatal (PD2), and prepubertal (PD90) exposure to an antiandrogen flutamide (50 mg/kg bw).

In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased AR and increased Cx43 expression, and altered localization of both proteins.

Moreover, enhanced apoptosis and reduced proliferation were detected in the prostates of these animals.

In PD90 males the alterations were less evident, except that Cx43 expression was markedly upregulated.

The results presented herein indicate that in boar androgen action during early fetal and neonatal periods plays a key role in the maintenance of normal phenotype and functions of prostatic cells at adulthood.

Furthermore, we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.

American Psychological Association (APA)

Hejmej, Anna& Górowska, Ewelina& Kotula-Balak, Malgorzata& Chojnacka, Katarzyna& Lydka-Zarzycka, Marta& Zając, Justyna…[et al.]. 2013. Androgen Signaling Disruption during Fetal and Postnatal Development Affects Androgen Receptor and Connexin 43 Expression and Distribution in Adult Boar Prostate. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030519

Modern Language Association (MLA)

Hejmej, Anna…[et al.]. Androgen Signaling Disruption during Fetal and Postnatal Development Affects Androgen Receptor and Connexin 43 Expression and Distribution in Adult Boar Prostate. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030519

American Medical Association (AMA)

Hejmej, Anna& Górowska, Ewelina& Kotula-Balak, Malgorzata& Chojnacka, Katarzyna& Lydka-Zarzycka, Marta& Zając, Justyna…[et al.]. Androgen Signaling Disruption during Fetal and Postnatal Development Affects Androgen Receptor and Connexin 43 Expression and Distribution in Adult Boar Prostate. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030519

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1030519