A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease
Joint Authors
De Falco, Elena
Chimenti, Isotta
Biondi-Zoccai, Giuseppe
D’Ascenzo, Fabrizio
Peruzzi, Mariangela
Cavarretta, Elena
Mancone, Massimo
Leoni, Omar
Caristo, Maria Emiliana
Lotrionte, Marzia
Marullo, Antonino G. M.
Amodeo, Antonio
Pacini, Luca
Petrozza, Vincenzo
Frati, Giacomo
Calogero, Antonella
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiac pathologies are among the leading causes of mortality and morbidity in industrialized countries, with myocardial infarction (MI) representing one of the major conditions leading to heart failure (HF).
Hitherto, the development of consistent, stable, and reproducible models of closed-chest MI in large animals, meeting the clinical realism of a patient with HF subsequent to chronic ischemic necrosis, has not been successful.
We hereby report the design and ensuing application of a novel porcine experimental model of closed-chest chronic ischemia suitable for biomedical research, mimicking post-MI HF.
We also emphasize the key procedural steps involved in replicating this unprecedented model, from femoral artery and vein catheterization to MI induction by permanent occlusion of the left anterior descending coronary artery through superselective deployment of platinum-nylon coils, as well as endomyocardial biopsy sampling for histologic analysis and cell harvesting.
Our model could indeed represent a valuable contribution and tool for translational research, providing precious insights to understand and overcome the many hurdles concerning, and currently quenching, the preclinical steps mandatory for the clinical translation of new cardiovascular technologies for personalized HF treatments.
American Psychological Association (APA)
Biondi-Zoccai, Giuseppe& De Falco, Elena& Peruzzi, Mariangela& Cavarretta, Elena& Mancone, Massimo& Leoni, Omar…[et al.]. 2013. A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030523
Modern Language Association (MLA)
Biondi-Zoccai, Giuseppe…[et al.]. A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030523
American Medical Association (AMA)
Biondi-Zoccai, Giuseppe& De Falco, Elena& Peruzzi, Mariangela& Cavarretta, Elena& Mancone, Massimo& Leoni, Omar…[et al.]. A Novel Closed-Chest Porcine Model of Chronic Ischemic Heart Failure Suitable for Experimental Research in Cardiovascular Disease. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030523