![](/images/graphics-bg.png)
Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach
Joint Authors
Yadav, Narayan Prasad
Yadav, Kuldeep Singh
Meher, Jaya Gopal
Pandey, Neelam
Luqman, Suaib
Chanda, Debabrata
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present work was aimed to develop an antiseptic cream formulation of Indian basil oil utilizing hydrophilic-lipophilic balance approach.
In order to determine the required-hydrophilic lipophilic balance (rHLB) of basil oil, emulsions of basil oil were prepared by phase inversion temperature technique using water, Tween 80, and Span 80.
Formulated emulsions were assessed for creaming (BE9; 9.8, BE10; 10.2), droplet size (BE18; 3.22 ± 0.09 μm), and turbidity (BE18; 86.12 ± 2.1%).
To ensure correctness of the applied methodology, rHLB of light liquid paraffin was also determined.
After rHLB determination, basil oil creams were prepared with two different combinations of surfactants, namely, GMS : Tween 80 (1 : 3.45) and SLS : GMS (1 : 3.68), and evaluated for in vitro antimicrobial activity, skin irritation test, viscosity and consistency.
The rHLB of basil oil and light liquid paraffin were found to be 13.36 ± 0.36 and 11.5 ± 0.35, respectively.
Viscosity, and consistency parameters of cream was found to be consistent over 90 days.
Cream formulations showed net zone of growth inhibition in the range of 5.0–11.3 mm against bacteria and 4.3–7.6 mm against fungi.
Primary irritation index was found to be between 0.38 and1.05.
Conclusively stable, consistent, non-irritant, enriched antiseptic basil oil cream formulations were developed utilizing HLB approach.
American Psychological Association (APA)
Yadav, Narayan Prasad& Meher, Jaya Gopal& Pandey, Neelam& Luqman, Suaib& Yadav, Kuldeep Singh& Chanda, Debabrata. 2013. Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030524
Modern Language Association (MLA)
Yadav, Narayan Prasad…[et al.]. Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030524
American Medical Association (AMA)
Yadav, Narayan Prasad& Meher, Jaya Gopal& Pandey, Neelam& Luqman, Suaib& Yadav, Kuldeep Singh& Chanda, Debabrata. Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030524