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Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma
Joint Authors
Santoni, Matteo
Cascinu, Stefano
Santoni, Giorgio
Berardi, Rossana
Burattini, Luciano
Amantini, Consuelo
Conti, Alessandro
Muzzonigro, Giovanni
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis.
VEGF expression in metastatic renal cell carcinoma (mRCC) is mostly regulated by hypoxia, predominantly via the hypoxia-induced factor (HIF)/Von Hippel-Lindau (VHL) pathway.
Advances in our knowledge of VEGF role in tumor angiogenesis, growth, and progression have permitted development of new approaches for the treatment of mRCC, including several agents targeting VEGF and VEGF receptors: tyrosine kinase pathway, serine/threonine kinases, α5β1-integrin, deacetylase, CD70, mammalian target of rapamycin (mTOR), AKT, and phosphatidylinositol 3′-kinase (PI3K).
Starting from sorafenib and sunitinib, several targeted therapies have been approved for mRCC treatment, with a long list of agents in course of evaluation, such as tivozanib, cediranib, and VEGF-Trap.
Here we illustrate the main steps of tumor angiogenesis process, defining the pertinent therapeutic targets and the efficacy and toxicity profiles of these new promising agents.
American Psychological Association (APA)
Conti, Alessandro& Santoni, Matteo& Amantini, Consuelo& Burattini, Luciano& Berardi, Rossana& Santoni, Giorgio…[et al.]. 2013. Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030533
Modern Language Association (MLA)
Conti, Alessandro…[et al.]. Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030533
American Medical Association (AMA)
Conti, Alessandro& Santoni, Matteo& Amantini, Consuelo& Burattini, Luciano& Berardi, Rossana& Santoni, Giorgio…[et al.]. Progress of Molecular Targeted Therapies for Advanced Renal Cell Carcinoma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030533