Expression and In Silico Analysis of the Recombinant Bovine Papillomavirus E6 Protein as a Model for Viral Oncoproteins Studies
Joint Authors
Stocco, Rita de Cassia
Carvalho, R. F.
Mazzuchelli-de-Souza, J.
Melo, T. C.
Beçak, W.
Araldi, R. P.
Ruiz, R. M.
Carvalho, E.
Thompson, C. E.
Sircili, Marcelo Palma
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bovine papillomaviruses (BPVs) are recognized as the causal agents of economical relevant diseases in cattle, associated with the development of tumors in skin and mucosa.
The oncogenesis process is mainly associated with different viral oncoprotein expressions, which are involved in cell transformation.
The expression and characterization of recombinant viral oncoproteins represent an attractive strategy to obtain biotechnological products as antibodies and potential vaccines, Thus, the aim of this work was to clone and express the BPV-1 and BPV-2 E6 recombinant proteins and perform in silico analysis in order to develop a strategy for the systematic study of other papillomaviruses oncoproteins.
The results demonstrated that BPV-1 and BPV-2 E6 recombinant proteins were expressed and purified from bacterial system as well as its in silico analysis was performed in order to explore and predict biological characteristics of these proteins.
American Psychological Association (APA)
Mazzuchelli-de-Souza, J.& Carvalho, R. F.& Ruiz, R. M.& Melo, T. C.& Araldi, R. P.& Carvalho, E.…[et al.]. 2013. Expression and In Silico Analysis of the Recombinant Bovine Papillomavirus E6 Protein as a Model for Viral Oncoproteins Studies. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030536
Modern Language Association (MLA)
Mazzuchelli-de-Souza, J.…[et al.]. Expression and In Silico Analysis of the Recombinant Bovine Papillomavirus E6 Protein as a Model for Viral Oncoproteins Studies. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030536
American Medical Association (AMA)
Mazzuchelli-de-Souza, J.& Carvalho, R. F.& Ruiz, R. M.& Melo, T. C.& Araldi, R. P.& Carvalho, E.…[et al.]. Expression and In Silico Analysis of the Recombinant Bovine Papillomavirus E6 Protein as a Model for Viral Oncoproteins Studies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030536