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Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer
Joint Authors
Mencalha, André Luiz
de Souza Fernandez, Cecília
de Souza Fernandez, Teresa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The human induced pluripotent stem cells (hiPSCs) are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors.
These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body.
So, the discovery of hiPSCs opens new opportunities in biomedical sciences, since these cells may be useful for understanding the mechanisms of diseases in the production of new diseases models, in drug development/drug toxicity tests, gene therapies, and cell replacement therapies.
However, the hiPSCs technology has limitations including the potential for the development of genetic and epigenetic abnormalities leading to tumorigenicity.
Nowadays, basic research in the hiPSCs field has made progress in the application of new strategies with the aim to enable an efficient production of high-quality of hiPSCs for safety and efficacy, necessary to the future application for clinical practice.
In this review, we show the recent advances in hiPSCs’ basic research and some potential clinical applications focusing on cancer.
We also present the importance of the use of statistical methods to evaluate the possible validation for the hiPSCs for future therapeutic use toward personalized cell therapies.
American Psychological Association (APA)
de Souza Fernandez, Teresa& de Souza Fernandez, Cecília& Mencalha, André Luiz. 2013. Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030542
Modern Language Association (MLA)
de Souza Fernandez, Teresa…[et al.]. Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030542
American Medical Association (AMA)
de Souza Fernandez, Teresa& de Souza Fernandez, Cecília& Mencalha, André Luiz. Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in Cancer. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030542