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Gelucire Based In Situ Gelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs
Joint Authors
Ghosh, Amitava
Saxena, Ashwin
Mishra, Arun K.
Verma, Navneet
Bhattacharya, Shiv S.
Verma, Anurag
Pandit, Jayanta K.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Non steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications to the geriatric patients for the treatment of arthritis and other painful disorders.
The major side effects of NSAIDs are related to their effects on the stomach and bowels.
The present study concerns assessment of the potential of liquid in situ gelling emulsion formulations (emulgels) as patient compliant stomach specific sustained release carrier for the delivery of highly gastric irritant drug, Piroxicam.
Emulgels were prepared, without using any emulgent, by mixing different concentrations of molten Gelucire 39/01 with low viscosity sodium alginate solution prepared in deionized water at 50°C.
CaCO3 was used as buoyancy imparting as well as crosslinking agent.
Emulgels so prepared were homogenous, physically stable, and rapidly formed into buoyant gelled mass when exposed to simulated gastric fluid (SGF, pH 1.2).
Drug release studies carried out in SGF revealed significant retardation (P<0.05) of Piroxicam release from emulgels compared to conventional in situ gelling formulations prepared without Gelucire 39/01.
Pharmacodynamic studies carried out in albino rats revealed significantly increased analgesic/anti-inflammatory response from in situ emulgels compared to conventional in situ gelling formulations.
Further, in vivo toxicity studies carried out in albino rats revealed no signs of gastric ulceration upon prolonged dosing.
American Psychological Association (APA)
Saxena, Ashwin& Mishra, Arun K.& Verma, Navneet& Bhattacharya, Shiv S.& Ghosh, Amitava& Verma, Anurag…[et al.]. 2013. Gelucire Based In Situ Gelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030549
Modern Language Association (MLA)
Saxena, Ashwin…[et al.]. Gelucire Based In Situ Gelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030549
American Medical Association (AMA)
Saxena, Ashwin& Mishra, Arun K.& Verma, Navneet& Bhattacharya, Shiv S.& Ghosh, Amitava& Verma, Anurag…[et al.]. Gelucire Based In Situ Gelling Emulsions: A Potential Carrier for Sustained Stomach Specific Delivery of Gastric Irritant Drugs. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030549
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030549