Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population
Joint Authors
Xu, Jin
Zhang, Lina
Ji, Lin-dan
Fei, Li-juan
Yuan, Fang
Zhang, Yue-miao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The association between polymorphisms of α-adducin (ADD1) gene and essential hypertension is still unclear.
Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population.
Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected.
Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer.
All 6 tag single nucleotide polymorphisms (tagSNPs) within ADD1 gene were genotyped by SNPstream genotyping system.
Multifactor dimensionality reduction (MDR) was used to identify the interactions among the SNPs and the non-genetic factors.
Results showed that plasma triglyceride, total cholesterol, and BMI were significantly higher in the hypertensive group than in the control group.
Result from genotyping indicated that rs4963 was significantly associated with essential hypertension.
After stratification by gender, rs4963 was associated with essential hypertension only in males.
MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension.
The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation.
American Psychological Association (APA)
Zhang, Lina& Ji, Lin-dan& Fei, Li-juan& Yuan, Fang& Zhang, Yue-miao& Xu, Jin. 2012. Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030551
Modern Language Association (MLA)
Zhang, Lina…[et al.]. Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030551
American Medical Association (AMA)
Zhang, Lina& Ji, Lin-dan& Fei, Li-juan& Yuan, Fang& Zhang, Yue-miao& Xu, Jin. Association between Polymorphisms of Alpha-Adducin Gene and Essential Hypertension in Chinese Population. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030551