Biomimetic Mineralization on a Macroporous Cellulose-Based Matrix for Bone Regeneration
Joint Authors
Petrauskaite, Odeta
Fernandes, Maria Helena
Juodzbalys, Gintaras
Stumbras, Arturas
Maminskas, Julius
Liesiene, Jolanta
Gomes, Pedro S.
Cicciù, Marco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study is to investigate the biomimetic mineralization on a cellulose-based porous matrix with an improved biological profile.
The cellulose matrix was precalcified using three methods: (i) cellulose samples were treated with a solution of calcium chloride and diammonium hydrogen phosphate; (ii) the carboxymethylated cellulose matrix was stored in a saturated calcium hydroxide solution; (iii) the cellulose matrix was mixed with a calcium silicate solution in order to introduce silanol groups and to combine them with calcium ions.
All the methods resulted in a mineralization of the cellulose surfaces after immersion in a simulated body fluid solution.
Over a period of 14 days, the matrix was completely covered with hydroxyapatite crystals.
Hydroxyapatite formation depended on functional groups on the matrix surface as well as on the precalcification method.
The largest hydroxyapatite crystals were obtained on the carboxymethylated cellulose matrix treated with calcium hydroxide solution.
The porous cellulose matrix was not cytotoxic, allowing the adhesion and proliferation of human osteoblastic cells.
Comparatively, improved cell adhesion and growth rate were achieved on the mineralized cellulose matrices.
American Psychological Association (APA)
Petrauskaite, Odeta& Gomes, Pedro S.& Fernandes, Maria Helena& Juodzbalys, Gintaras& Stumbras, Arturas& Maminskas, Julius…[et al.]. 2013. Biomimetic Mineralization on a Macroporous Cellulose-Based Matrix for Bone Regeneration. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030552
Modern Language Association (MLA)
Petrauskaite, Odeta…[et al.]. Biomimetic Mineralization on a Macroporous Cellulose-Based Matrix for Bone Regeneration. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030552
American Medical Association (AMA)
Petrauskaite, Odeta& Gomes, Pedro S.& Fernandes, Maria Helena& Juodzbalys, Gintaras& Stumbras, Arturas& Maminskas, Julius…[et al.]. Biomimetic Mineralization on a Macroporous Cellulose-Based Matrix for Bone Regeneration. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030552