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Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Montoya-Buelna, Margarita
Tovar-Cuevas, Alvaro J.
Alvarado-Navarro, Anabell
Valle, Yeminia
Muñoz-Valle, Jose F.
Figuera-Villanueva, Luis Eduardo
Fafutis-Morris, M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Leprosy is a debilitating infectious disease of human skin and nerves.
Genetics factors of the host play an important role in the disease susceptibility.
Toll-interacting protein (TOLLIP) is an inhibitory adaptor protein within the toll-like receptor (TLR) pathway, which recognizes structurally conserved molecular patterns of microbial pathogens, initiating immune responses.
The objective of this study was to investigate the association of variants in the TOLLIP gene with susceptibility to leprosy in Mexican patients.
Methods.
TOLLIP polymorphisms were studied using a case-control design of Mexican patients with lepromatous leprosy (LL).
The polymorphisms of TOLLIP at loci −526 C>G (rs5743854), 1309956C>T (rs3750920), 1298430C>A (rs5744015), and 1292831 G>A (rs3750919) were analyzed by PCR, with sequence-specific primers in LL patients and healthy subjects (HS) as controls.
Results.
Genotype distributions were in Hardy Weinberg equilibrium for all sites except for rs3750920.
Neither genotype nor allele frequencies were statistically different between LL patients and controls (P>0.05).
The maximum pairwise D’ coefficient reached was 0.44 of linkage (P=0.01) for all the polymorphisms except for rs5743854.
The three loci haplotype comparison yielded no significant differences between groups.
Conclusions.
Just the individuals with genotype C/C of rs3750920 have a trend of protective effect to developing LL.
American Psychological Association (APA)
Montoya-Buelna, Margarita& Fafutis-Morris, M.& Tovar-Cuevas, Alvaro J.& Alvarado-Navarro, Anabell& Valle, Yeminia& Padilla-Gutiérrez, Jorge Ramón…[et al.]. 2013. Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030559
Modern Language Association (MLA)
Montoya-Buelna, Margarita…[et al.]. Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030559
American Medical Association (AMA)
Montoya-Buelna, Margarita& Fafutis-Morris, M.& Tovar-Cuevas, Alvaro J.& Alvarado-Navarro, Anabell& Valle, Yeminia& Padilla-Gutiérrez, Jorge Ramón…[et al.]. Role of Toll-Interacting Protein Gene Polymorphisms in Leprosy Mexican Patients. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030559