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Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration by Bixa orellana Leaf Extract
Joint Authors
Ahmad, Zuraini
Sulaiman, NurShahira
Hakim, Muhammad Nazrul
Zakaria, Zainul Amirudin
Othman, Fauziah
Ee, Gwendoline Cheng Lian
Yong, Yoke Keong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to evaluate the anti-inflammatory activities of aqueous extract of Bixa orellana (AEBO) leaves and its possible mechanisms in animal models.
The anti-inflammatory activity of the extract was evaluated using serotonin-induced rat paw edema, increased peritoneal vascular permeability, and leukocyte infiltrations in an air-pouch model.
Nitric oxide (NO), indicated by the sum of nitrites and nitrates, and vascular growth endothelial growth factor (VEGF) were measured in paw tissues of rats to determine their involvement in the regulation of increased permeability.
Pretreatments with AEBO (50 and 150 mg kg−1) prior to serotonin inductions resulted in maximum inhibitions of 56.2% of paw volume, 45.7% of Evans blue dye leakage in the peritoneal vascular permeability model, and 83.9% of leukocyte infiltration in the air-pouch model.
57.2% maximum inhibition of NO and 27% of VEGF formations in rats’ paws were observed with AEBO at the dose of 150 mg kg−1.
Pharmacological screening of the extract showed significant (P<0.05) anti-inflammatory activity, indicated by the suppressions of increased vascular permeability and leukocyte infiltration.
The inhibitions of these inflammatory events are probably mediated via inhibition of NO and VEGF formation and release.
American Psychological Association (APA)
Yong, Yoke Keong& Sulaiman, NurShahira& Hakim, Muhammad Nazrul& Ee, Gwendoline Cheng Lian& Zakaria, Zainul Amirudin& Othman, Fauziah…[et al.]. 2013. Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration by Bixa orellana Leaf Extract. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030567
Modern Language Association (MLA)
Yong, Yoke Keong…[et al.]. Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration by Bixa orellana Leaf Extract. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030567
American Medical Association (AMA)
Yong, Yoke Keong& Sulaiman, NurShahira& Hakim, Muhammad Nazrul& Ee, Gwendoline Cheng Lian& Zakaria, Zainul Amirudin& Othman, Fauziah…[et al.]. Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration by Bixa orellana Leaf Extract. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030567