Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases
Joint Authors
Hsieh, Hsi-Lung
Yang, Chuen-Mao
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Reactive oxygen species (ROS), a redox signal, are produced by various enzymatic reactions and chemical processes, which are essential for many physiological functions and act as second messengers.
However, accumulating evidence has implicated the pathogenesis of several human diseases including neurodegenerative disorders related to increased oxidative stress.
Under pathological conditions, increasing ROS production can regulate the expression of diverse inflammatory mediators during brain injury.
Elevated levels of several proinflammatory factors including cytokines, peptides, pathogenic structures, and peroxidants in the central nervous system (CNS) have been detected in patients with neurodegenerative diseases such as Alzheimer’s disease (AD).
These proinflammatory factors act as potent stimuli in brain inflammation through upregulation of diverse inflammatory genes, including matrix metalloproteinases (MMPs), cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2), and adhesion molecules.
To date, the intracellular signaling mechanisms underlying the expression of target proteins regulated by these factors are elusive.
In this review, we discuss the mechanisms underlying the intracellular signaling pathways, especially ROS, involved in the expression of several inflammatory proteins induced by proinflammatory factors in brain resident cells.
Understanding redox signaling transduction mechanisms involved in the expression of target proteins and genes may provide useful therapeutic strategies for brain injury, inflammation, and neurodegenerative diseases.
American Psychological Association (APA)
Hsieh, Hsi-Lung& Yang, Chuen-Mao. 2013. Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases. BioMed Research International،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1030586
Modern Language Association (MLA)
Hsieh, Hsi-Lung& Yang, Chuen-Mao. Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases. BioMed Research International No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-1030586
American Medical Association (AMA)
Hsieh, Hsi-Lung& Yang, Chuen-Mao. Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-1030586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030586