The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis
Joint Authors
Jawed, Huma
Shah, Syed Uzair A.
Awan, Shahid I.
Anjum, Shazia
Simjee, Shabana Usman
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is potentially devastating condition which lacks good treatment options.
Pro-inflammatory cytokines interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and oxidative stress markers such as nitric oxide (NO) and peroxide (PO) are mediators of RA pathogenesis.
In the present study N-[2,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-3-yl]acrylamide (NHAG), analogue of glucosamine, was evaluated in adjuvant-induced arthritic model of rats.
The disease progression was monitored by analysing arthritis scoring, loss of body weight, paw oedema, and histological changes in joints.
RA associated hyperalgesia was evaluated by gait analysis.
The serum or plasma levels of NO, PO, glutathione (GSH) superoxide dismutase (SOD) IL-1β and TNF-α were analyzed to monitor the state of disease severity.
The arthritic control animals exhibited significant increase in arthritic score (P<0.003) and paw oedema (P<0.001) with parallel loss in body weight (P<0.04).
The NHAG-treated arthritic animals exhibited refinement in the gait changes associated with arthritis.
NHAG also significantly decreased the NO (P<0.02) and PO (P<0.03) with concurrent increased in GSH (P<0.04) and SOD (P<0.007).
Both IL-1β (P<0.001) and TNF-α (P<0.001), were significantly decreased in NHAG-treated group.
Thus NHAG might have a therapeutic potential for arthritis by exerting antioxidative and immunomodulatory effects.
American Psychological Association (APA)
Shah, Syed Uzair A.& Jawed, Huma& Awan, Shahid I.& Anjum, Shazia& Simjee, Shabana Usman. 2013. The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030591
Modern Language Association (MLA)
Shah, Syed Uzair A.…[et al.]. The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis. BioMed Research International No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-1030591
American Medical Association (AMA)
Shah, Syed Uzair A.& Jawed, Huma& Awan, Shahid I.& Anjum, Shazia& Simjee, Shabana Usman. The Anti-Arthritic and Immune-Modulatory Effects of NHAG: A Novel Glucosamine Analogue in Adjuvant-Induced Arthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-1030591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030591