Endometrial Polyps in Women Affected by Levothyroxine-Treated Hypothyroidism—Histological Features, Immunohistochemical Findings, and Possible Explanation of Etiopathogenic Mechanism: A Pilot Study
Joint Authors
Gangemi, Michele
Saccardi, Carlo
Ludwig, Kathrin
Guido, Maria
Scarton, Mara
Tinelli, Raffaele
Gizzo, Salvatore
Litta, Pietro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of the study was to investigate the possible overexpression of estrogen (ERs) and progesterone (PRs) receptors both in EPs glandular and stromal cells in postmenopausal women with levothyroxine-treated hypothyroidism in comparison to EPs detected in women with physiological thyroid hormone levels.
During the study period (January-February 2013) 22 patients were eligible (12 treated, 10 controls).
The two groups were homogenous for general, EPs sonographic and hysteroscopic features.
None of the cases of atypia was found.
Immunohistochemistry showed that the two groups were similar for ERs and PRs intensity rates in EPs glandular cells despite a trend of ERs percentage expression more than 60% in 2/3 of treated patients versus 1/3 of controls.
In stromal EPs components, ERs intensity was high positive in 10 (83,3%) treated cases while it was high positive in 1 control (10%).
Percentage of ERs stromal expression showed a different trend between the two groups despite a borderline statistical significance.
Our hypothesis is based on a possible double action of hypothyroidism and thyroxine intake: the subclinical TSH increased levels and its possible circadian oscillation could stimulate the endometrial TSHRs (increasing type 2 DIO activity); the circulating levels of exogenous thyroxine could be locally metabolized in active form by type 2 DIO stimulating ERs.
American Psychological Association (APA)
Saccardi, Carlo& Gizzo, Salvatore& Ludwig, Kathrin& Guido, Maria& Scarton, Mara& Gangemi, Michele…[et al.]. 2013. Endometrial Polyps in Women Affected by Levothyroxine-Treated Hypothyroidism—Histological Features, Immunohistochemical Findings, and Possible Explanation of Etiopathogenic Mechanism: A Pilot Study. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030607
Modern Language Association (MLA)
Saccardi, Carlo…[et al.]. Endometrial Polyps in Women Affected by Levothyroxine-Treated Hypothyroidism—Histological Features, Immunohistochemical Findings, and Possible Explanation of Etiopathogenic Mechanism: A Pilot Study. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030607
American Medical Association (AMA)
Saccardi, Carlo& Gizzo, Salvatore& Ludwig, Kathrin& Guido, Maria& Scarton, Mara& Gangemi, Michele…[et al.]. Endometrial Polyps in Women Affected by Levothyroxine-Treated Hypothyroidism—Histological Features, Immunohistochemical Findings, and Possible Explanation of Etiopathogenic Mechanism: A Pilot Study. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030607