The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing
Joint Authors
Guo, Shi-Lei
Xu, Yan
Wang, Ying
Zhu, Fen
Xu, Yang
Yin, Zhi-qiang
Zhou, Bing-rong
Wu, Di
Permatasari, Felicia
Luo, Dan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin.
Materials and Methods.
Nineteen subjects were treated with FxCR on the bilateral inner arms.
ADSC-CM was applied on FxCR site of one randomly selected arm.
Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured.
Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted.
Results.
The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side.
The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group.
Conclusion.
Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.
American Psychological Association (APA)
Zhou, Bing-rong& Xu, Yang& Guo, Shi-Lei& Xu, Yan& Wang, Ying& Zhu, Fen…[et al.]. 2013. The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030619
Modern Language Association (MLA)
Zhou, Bing-rong…[et al.]. The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030619
American Medical Association (AMA)
Zhou, Bing-rong& Xu, Yang& Guo, Shi-Lei& Xu, Yan& Wang, Ying& Zhu, Fen…[et al.]. The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030619